ABNORMAL T2-WI SIGNAL IN CHRONIC EPILEPTIC RATS INDUCED BY DELIVERING REPETITIVE TETANUS INTO THE APICAL DENDRITE REGION IN 
EITHER CA1 OR DENTATE GYRUS

Chinese Journal of Magnetic Resonance ›› 2001, Vol. 18 ›› Issue (3): 193-200.

ABNORMAL T₂-WI SIGNAL IN CHRONIC EPILEPTIC RATS INDUCED BY DELIVERING REPETITIVE TETANUS INTO THE APICAL DENDRITE REGION IN
EITHER CA1 OR DENTATE GYRUS

ZANG Ying¹, HAN Dan¹*, YANG Yun-huang², LIU Mai-li², ZHOU Zu-yu³, ZENG Jun³

1.Department of Physiology, Medical College, Wuhan University, Wuhan 430071; 2.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Science, Wuhan 430071; 3.Department of Pathology, Medical College, Wuhan University, Wuhan 430071

Received:2001-04-17 Revised:2001-06-06 Published:2001-09-05 Online:2001-09-05
About author:*Correspondence author
Supported by:
波谱与原子分子物理国家重点实验室开放基金资助项目(N o:99T1509) 和湖北省自然科学基金资助项目（No:29925515）.

Abstract

Abstract:

The chronic rat temporal epilepsy was induced by repetitive tetanus (60Hz, 0.4～0.6mA , 2s) to the apical dendrite region (ADR) in either CA1 or the dentate gyrus ( DG ) once a day for 6 or 8 days. T₂-weighted MRI (T₂-WI) measurements and morpholog ical observations were performed on the tetanized rats. A resemble increase of MRI signal intensity in the lateral ventricle area was observed both in the ADR- tetanized rats and the DG-tetanized rats. There is an asymmetric T₂-WI ab normaliti es in the anterior MRI slices and ventral T₂-WI abnormalities contralater al to t he implantation side in the posterior MRI slices (1 mm posterior to the anterior MRI slice). Morphological identification showed that there are the enlarged lat e ral ventricle and pathological ventricular chorodea plexus hyperplasia which cor respond to the MRI observations. The results suggested that the activation of DG or ADR in an intrinsic hippocampal circuit may play the same role in epileptogenesis.

Key words: Apical dendrite, Dentate gyrus, MRI, Epilepsy, Rats

CLC Number:

R816.1

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ABNORMAL T₂-WI SIGNAL IN CHRONIC EPILEPTIC RATS INDUCED BY DELIVERING REPETITIVE TETANUS INTO THE APICAL DENDRITE REGION IN
EITHER CA1 OR DENTATE GYRUS

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