Sequence Development and Parameter Optimization for A Pseudo-Continuous Arterial Spin Labeling Method on 1.5 T Clinical Magnetic Resonance Imaging Systems

doi:10.11938/cjmr20150403

Chinese Journal of Magnetic Resonance ›› 2015, Vol. 32 ›› Issue (4): 574-583.doi: 10.11938/cjmr20150403

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Sequence Development and Parameter Optimization for A Pseudo-Continuous Arterial Spin Labeling Method on 1.5 T Clinical Magnetic Resonance Imaging Systems

WEI Qing^1,2，SONG Rui-bo²，ZHOU Xiao-dong²，TANG Wei-jun⁴，ZHANG Wei-guo³，CHEN Qun¹*

1. Medical Imaging Technology Section (Shanghai Advanced Research Institute, Chinese Academy of Sciences), Shanghai 201210, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China;
3. Shanghai United Imaging Healthcare Cooperation, Shanghai 201815, China;
4. Huashan Hospital, Shanghai 200031, China

Received:2014-12-12 Revised:2015-10-28 Published:2015-12-05 Online:2015-12-05
About author:*Corresponding author： CHEN Qun, Tel: +86-21-67076980, E-mail: qun.chen@sari.ac.cn.
Supported by:
中国科学院重点部署资助项目(Y325511211)

Abstract

Abstract:

Pseudo-continuous arterial spin labeling (pCASL) is perfusion imaging technique that combines the advantages of continuous arterial spin labeling (CASL) and pulsed arterial spin labeling (PASL). In this study, we implemented a pCASL sequence on uMR560 1.5 T MRI systems developed by United Imaging Healthcare Cooperation. Experiments were performed to demonstrate the stability of the pCASL sequence implemented and the accuracy of perfusion quantification. The tagging efficiency was first measured through phantom experiments. In order to achieve the highest signal-to-noise ratio, post-labeling delay time and labeling distance were optimized empirically to be approximately 70 mm blow the imaging slab and 1 200 ms, respectively. Lastly, perfusion-weighted signal intensity and absolute cerebral blood flow (CBF) were measured from 12 normal volunteers using the pCASL sequence implemented, with satisfactory results obtained from 10 subjects. In summary, the pCASL sequence implemented on the uMR560 1.5 T MRI systems can be used for perfusion imaging on human brain, with reasonable stability and accuracy.

Key words: pseudo-continuous arterial spin labeling, cerebral blood flow, tagging distance, post labeling delay time

CLC Number:

O482.53

WEI Qing1,2，SONG Rui-bo2，ZHOU Xiao-dong2，TANG Wei-jun4，ZHANG Wei-guo3，CHEN Qun1*. Sequence Development and Parameter Optimization for A Pseudo-Continuous Arterial Spin Labeling Method on 1.5 T Clinical Magnetic Resonance Imaging Systems
[J]. Chinese Journal of Magnetic Resonance, 2015, 32(4): 574-583.

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Sequence Development and Parameter Optimization for A Pseudo-Continuous Arterial Spin Labeling Method on 1.5 T Clinical Magnetic Resonance Imaging Systems

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