Chinese Journal of Magnetic Resonance

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 STUDY OF DIFFUSION COEFFICIENT DISTRIBUTION OFLIPOPROTEINS BY PULSE-FIELD-GRADIENT (PFG)-NMR

CUI Yan-fang1,2, WEN Jian3, LIU Mai-li1*
  

  1. 1.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071, China; 2.Department of Chemistry, Central China Normal University, Wuhan 430079, China; 3.Institute of Pharmacology, Wuhan University, Wuhan 430071, China
  • Received:2002-02-06 Revised:2002-11-15 Published:2003-03-05 Online:2003-03-05
  • About author:*Correspondence author: Tel:027-8719-7305, Fax:027-8719-9291,E-mail:ml.liu@wipm.ac.cn
  • Supported by:

    国家自然科学基金资助项目(29925515).

Abstract:

Qualitative and quantitative analysis of major fractions of lipoproteins such as LDL, VLDL and HDL, has great values in many biomedical applications, for instance, in the diagnosis of liver diseases, heart diseases and cancer, and in diet management. A method of using a continuous distribution model of diffusion coefficient to characterize lipoproteins was developed in this study. Commercial samples of HDL, LDL and their mixtures at HDL∶LDL ratios of 2∶1 and 1∶1 were used to test the validity of this approach. The results showed that, with the samples studied, the continuous distribution model of diffusion coefficient resulted in good fitting to experimental data.

Key words: NMR, diffusion coefficient, lipoprotein, distribution function, pulse-field-gradient

CLC Number: