Chinese Journal of Magnetic Resonance ›› 2010, Vol. 27 ›› Issue (1): 80-88.

Previous Articles     Next Articles

Succinimide-Linked Nitrone: Synthesis and  ESR Studies

  

  1. 1.Inner Mongolia University of Technology, College of Chemical Engineering, Inner Mongolian Autonomous Region, Hohhot 010051, China;
    2.State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China;
    3.Faculty of Sciences, Beijing University of Chemical Technology, Beijing 100029, China;
    4.College of Life Science, Sichuan University, Chengdu 610064, China
  • Received:2009-12-30 Published:2010-03-05 Online:2010-03-05
  • Supported by:

    国家自然科学基金资助项目(90813021, 20875093);中国科学院研发实验服务基地资助基金.

Abstract:

A novel linear nitrone spin-trap, DSC-PBN (N-(4-(((2,5-dioxopyrrolidin-1-yloxy)carbonyloxy)methyl)benzylidene)-2-methylpropan-2-N-oxide), was designed and synthesized. Its structure was characterized by UV, MS and 1H NMR techniques. ESR results showed that the compound could be used to trap various free radicals efficiently, and the ESR spectra of the trapped radicals were readily recognizable. DSC-PBN could easily form a covalent link to the N-terminal peptides (or proteins) via succinimide intermediates, thus showing high potential for biological applications.

Key words: spin trap, nitrone, [ free radicals, electron spin resonance (ESR)

CLC Number: