波谱学杂志

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扩散加权磁共振波谱采集策略优化:门控及循环模式影响

文玉林1,2,李改英1,2*,武玉朋1,2,李建奇1,2
  

  1. 1. 华东师范大学 物理与电子科学学院,上海市磁共振重点实验室,上海 200062;2. 华东师范大学 医学磁共振与分子影像技术研究院,上海 200062 
  • 收稿日期:2025-04-02 修回日期:2025-05-10 出版日期:2025-05-12 在线发表日期:2025-05-12
  • 通讯作者: 李改英 E-mail:ligaiying@phy.ecnu.edu.cn

Optimization of DW-MRS Acquisition Protocol: The Impact of Gating and Cycling Modes

WEN Yulin1,2, LI Gaiying1,2*,WU Yupeng1,2,LI Jianqi1,2   

  1. 1. Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China; 2. Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai 200062, China
  • Received:2025-04-02 Revised:2025-05-10 Published:2025-05-12 Online:2025-05-12
  • Contact: LI Gaiying E-mail:ligaiying@phy.ecnu.edu.cn

摘要:

扩散加权磁共振波谱(DW-MRS)可用于测量代谢物表观扩散系数(ADC),从而特异性地表征细胞微结构特性. 然而,生理运动伪影和较低的测量重复性限制了其临床应用. 本文探究了不同门控方法和循环模式对DW-MRS结果的影响. 研究共纳入21名健康受试者,其中6名分别采用心电门控、呼吸门控和无门控策略对辐射冠及后扣带回皮层区域进行扫描,对比信号衰减情况;另15名分别使用b值内循环与外循环模式进行扫描,评估循环模式对ADC测量可重复性的影响. 结果表明,心电门控可显著抑制生理运动伪影并降低ADC高估现象,且在辐射冠区域效果尤为明显,而呼吸门控的改善作用相对有限. 此外,b值内循环可提升ADC可重复性. 因此,结合心电门控与b值内循环技术可有效降低运动伪影,提高ADC可靠性,为DW-MRS临床应用提供技术支持. 

关键词: 扩散加权磁共振波谱, 表观扩散系数, 采集策略优化, 门控技术, 循环模式

Abstract:

Diffusion-weighted magnetic resonance spectroscopy (DW-MRS) measures metabolite apparent diffusion coefficients (ADC) to characterize cellular microstructures. However, physiological motion artifacts and low reproducibility limit its clinical application. This study investigates the effects of different gating methods and cycling modes on DW-MRS results. Twenty-one healthy subjects were included: Six underwent DW-MRS scans using electrocardiogram (ECG) gating, respiratory gating, or no gating, while the remaining 15 were scanned using internal and external b-value cycling to evaluate the impact of cycling modes on ADC reproducibility. ECG gating reduced motion artifacts and mitigated ADC overestimation, while internal cycling improved reproducibility. The combination of ECG gating and internal cycling enhances ADC reliability, supporting the broader clinical application of DW-MRS.

Key words: Diffusion-weighted Magnetic Resonance Spectroscopy, Apparent Diffusion Coefficient, Optimization of Acquisition Protocol, Gating Techniques, Cycling Mode

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