扩散加权磁共振波谱采集策略优化：门控及循环模式影响

doi:10.11938/cjmr20253156

摘要/Abstract

摘要：

扩散加权磁共振波谱（DW-MRS）可用于测量代谢物表观扩散系数（ADC），从而特异性地表征细胞微结构特性. 然而，生理运动伪影和较低的测量重复性限制了其临床应用. 本文探究了不同门控方法和循环模式对DW-MRS结果的影响. 研究共纳入21名健康受试者，其中6名分别采用心电门控、呼吸门控和无门控策略对辐射冠及后扣带回皮层区域进行扫描，对比信号衰减情况；另15名分别使用b值内循环与外循环模式进行扫描，评估循环模式对ADC测量可重复性的影响. 结果表明，心电门控可显著抑制生理运动伪影并降低ADC高估现象，且在辐射冠区域效果尤为明显，而呼吸门控的改善作用相对有限. 此外，b值内循环可提升ADC可重复性. 因此，结合心电门控与b值内循环技术可有效降低运动伪影，提高ADC可靠性，为DW-MRS临床应用提供技术支持.

关键词: 扩散加权磁共振波谱, 表观扩散系数, 采集策略优化, 门控技术, 循环模式

Abstract:

Diffusion-weighted magnetic resonance spectroscopy (DW-MRS) measures metabolite apparent diffusion coefficients (ADC) to characterize cellular microstructures. However, physiological motion artifacts and low reproducibility limit its clinical application. This study investigates the effects of different gating methods and cycling modes on DW-MRS results. A total of 21 healthy subjects were included: 6 underwent DW-MRS scans under electrocardiogram (ECG) gating, respiratory gating, and no gating; the remaining 15 were scanned using internal and external b-value cycling to evaluate the impact of cycling modes on ADC reproducibility. Results showed that ECG gating reduced motion artifacts and mitigated ADC overestimation, while internal cycling improved reproducibility. The combination of ECG gating and internal cycling enhances ADC reliability, supporting the broader clinical application of DW-MRS.

Key words: diffusion-weighted magnetic resonance spectroscopy (DW-MRS), apparent diffusion coefficient (ADC), optimization of acquisition protocol, gating techniques, cycling mode

中图分类号:

O482.53

文玉林, 李改英, 武玉朋, 李建奇. 扩散加权磁共振波谱采集策略优化：门控及循环模式影响[J]. 波谱学杂志, 2025, 42(4): 402-413.

WEN Yulin, LI Gaiying, WU Yupeng, LI Jianqi. Optimization of DW-MRS Acquisition Protocol: The Impact of Gating and Cycling Modes[J]. Chinese Journal of Magnetic Resonance, 2025, 42(4): 402-413.

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		ADC/(μm²/ms)			P₁₂	P₁₃	P₂₃
		Cardiac gating	Respiratory gating	No gating	P₁₂	P₁₃	P₂₃
tCho	LR	0.144 ± 0.043	0.147 ± 0.017	0.164 ± 0.030	0.850	0.287	0.377
	AP	0.116 ± 0.030	0.118 ± 0.026	0.135 ± 0.016	0.842	0.073	0.105
	HF	0.134 ± 0.013	0.152 ± 0.027	0.178 ± 0.036	0.193	0.005**	0.077
	mean	0.131 ± 0.023	0.139 ± 0.018	0.159 ± 0.025	0.477	0.023*	0.091
tCr	LR	0.166 ± 0.045	0.191 ± 0.023	0.193 ± 0.034	0.151	0.204	0.858
	AP	0.141 ± 0.026	0.167 ± 0.024	0.170 ± 0.020	0.072	0.049*	0.839
	HF	0.162 ± 0.018	0.185 ± 0.015	0.195 ± 0.026	0.059	0.012*	0.428
	mean	0.156 ± 0.025	0.181 ± 0.012	0.186 ± 0.024	0.044*	0.028*	0.817
tNAA	LR	0.171 ± 0.041	0.186 ± 0.017	0.200 ± 0.038	0.432	0.125	0.427
	AP	0.161 ± 0.020	0.179 ± 0.027	0.182 ± 0.023	0.076	0.046*	0.794
	HF	0.153 ± 0.020	0.171 ± 0.016	0.193 ± 0.027	0.054	<0.001***	0.016*
	mean	0.162 ± 0.018	0.178 ± 0.013	0.192 ± 0.022	0.081	0.004**	0.157

		ADC/(μm²/ms)			P₁₂	P₁₃	P₂₃
		Cardiac gating	Respiratory gating	No gating	P₁₂	P₁₃	P₂₃
tCho	LR	0.106 ± 0.024	0.112 ± 0.020	0.111 ± 0.023	0.674	0.721	0.949
	AP	0.097 ± 0.027	0.099 ± 0.011	0.108 ± 0.018	0.876	0.346	0.428
	HF	0.092 ± 0.019	0.111 ± 0.023	0.111 ± 0.021	0.003**	0.003**	0.955
	mean	0.098 ± 0.019	0.107 ± 0.014	0.110 ± 0.014	0.303	0.178	0.734
tCr	LR	0.130 ± 0.017	0.151 ± 0.015	0.139 ± 0.015	0.034*	0.364	0.185
	AP	0.114 ± 0.015	0.129 ± 0.013	0.131 ± 0.013	0.041*	0.022*	0.747
	HF	0.105 ± 0.009	0.119 ± 0.014	0.127 ± 0.015	0.055	0.004**	0.215
	mean	0.116 ± 0.008	0.133 ± 0.012	0.132 ± 0.014	0.019*	0.023*	0.928
tNAA	LR	0.144 ± 0.030	0.148 ± 0.009	0.142 ± 0.012	0.750	0.826	0.592
	AP	0.120 ± 0.016	0.125 ± 0.008	0.128 ± 0.006	0.431	0.205	0.614
	HF	0.113 ± 0.013	0.124 ± 0.016	0.130 ± 0.017	0.219	0.073	0.529
	mean	0.126 ± 0.018	0.132 ± 0.008	0.133 ± 0.009	0.368	0.303	0.893

		ADC/(μm²/ms)		P values
		Internal b-value cycling	External b-value cycling	P values
tCho	LR	0.109 ± 0.014	0.109 ± 0.019	0.826
	AP	0.112 ± 0.018	0.104 ± 0.024	0.158
	HF	0.097 ± 0.016	0.099 ± 0.021	0.614
	mean	0.106 ± 0.011	0.104 ± 0.018	0.601
tCr	LR	0.133 ± 0.014	0.134 ± 0.019	0.680
	AP	0.117 ± 0.016	0.120 ± 0.020	0.542
	HF	0.110 ± 0.011	0.109 ± 0.014	0.749
	mean	0.120 ± 0.010	0.121 ± 0.015	0.883
tNAA	LR	0.144 ± 0.017	0.143 ± 0.021	0.806
	AP	0.121 ± 0.008	0.122 ± 0.013	0.486
	HF	0.117 ± 0.014	0.116 ± 0.016	0.637
	mean	0.127 ± 0.011	0.127 ± 0.013	0.780